Fig. 3
Evaluation of chiral ligands. Reaction conditions: 1a (0.10 mmol), 5a (0.20 mmol), [Rh(COD)Cl]2 (4 mol%), L (8 mol%), (PhO)2P(O)(OH) (8 mol%), CH2Cl2 (0.2 mL), 30 °C, 18 h. Yields and product ratios were determined by 1H NMR analysis of the unpurified reaction mixture using dimethyl terephthalate as an internal standard. Enantioselectivities (er’s) were determined by chiral SFC analysis. aUsing [Rh(COD)Cl]2 (2 mol%), L (4 mol%), (PhO)2P(O)(OH) (4 mol%), CH2Cl2 (0.1 mL)
