Fig. 4
Enantioselective semireduction of allenes. Reaction conditions: 1 (0.20 mmol), 5a (0.40 mmol), [Rh(COD)Cl]2 (2 mol%), L6 (4 mol%), (PhO)2P(O)(OH) (4 mol%), CH2Cl2 (0.2 mL), 30 °C, 18 h. Isolated yields. Product ratios were determined by 1H NMR analysis of the unpurified reaction mixture. Enantioselectivities (er’s) were determined by chiral SFC analysis. aReaction performed with 1,2-dichloroethane at 60 °C
