Table 1 Pharmacodynamic parameters after application of drops containing four concentrations of pregabalin to the eyes of B6 mice
Pharmacodynamic parameters (mean ± SEM) | Pregabalin eye drops | |||
|---|---|---|---|---|
0.3% | 0.6% | 0.9% | 1.2% | |
Baseline IOP (mmHg) | 15.4 ± 0.3 | 15.4 ± 0.1 | 15.3 ± 0.1 | 15.5 ± 0.1 |
IOP at T max (mmHg) | — | 14.2 ± 0.7 | 12.7 ± 0.8 | 12.6 ± 0.8 |
∆IOP (mmHg) | — | −1.2 ± 0.8 | −2.7 ± 0.8 | −2.9 ± 0.9 |
% Reduction in IOP | — | 7.8 ± 4.8 | 17.3 ± 5.4 | 18.4 ± 5.6 |
T max (h) | — | 3.0 ± 0.4 | 2.8 ± 0.5 | 3.4 ± 0.4 |
T end (h) | — | 5.5 ± 0.3 | 6.0 ± 0.4 | 6.8 ± 0.2 |
AUCtotal (% h) | — | 42.9 ± 11.1 | 67.1 ± 19.1 | 71.9 ± 12.1 |
Statistical comparisons among four concentrations of pregabalin drops applied to the eyes of B6 mice | |||||||
|---|---|---|---|---|---|---|---|
Pharmacodynamic parameters (mean ± SEM) | Overall P-value | 0.3% vs. 0.6% | 0.3% vs. 0.9% | 0.3% vs. 1.2% | 0.6% vs. 0.9% | 0.6% vs. 1.2% | 0.9% vs. 1.2% |
% Reduction in IOP | 0.034 | >0.05 | >0.05 | <0.05 | >0.05 | >0.05 | >0.05 |
T max (h) | <0.0001 | <0.001 | <0.001 | <0.0001 | >0.05 | >0.05 | >0.05 |
T end (h) | <0.0001 | <0.0001 | <0.0001 | <0.0001 | >0.05 | <0.05 | >0.05 |
AUCtotal (% h) | 0.002 | >0.05 | <0.01 | <0.01 | >0.05 | >0.05 | >0.05 |
