Table 2 Pharmacodynamic parameters after application of 0.9% pregabalin eye drops to D2, BXD48 (D allele), B6, and BXD14 (B allele) mice

From: Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Pharmacodynamic parameters (mean ± SEM)

Mouse strain

 

D2

BXD48

B6

BXD14

Baseline IOP (mmHg)

17.2 ± 0.3

16.8 ± 0.5

15.3 ± 0.1

17.8 ± 0.6

IOP at T max (mmHg)

—

14.4 ± 0.7

12.7 ± 0.8

12.7 ± 0.5

∆IOP (mmHg)

—

−2.4 ± 0.6

−2.7 ± 0.8

−5.1 ± 0.8

% Reduction in IOP

—

14.3 ± 3.9

17.3 ± 5.4

28.6 ± 3.5

T max (h)

—

1.5 ± 0.2

2.8 ± 0.5

3.2 ± 0.3

T end (h)

—

3.0 ± 0.5

6.0 ± 0.4

6.5 ± 0.3

AUCtotal (% h)

—

26.6 ± 4.5

67.1 ± 19.1

88.7 ± 12.6

Statistical comparisons among different strains of mice after application of 0.9% pregabalin eye drops

Pharmacodynamic parameters (mean ± SEM)

Overall P-value

D2 vs. BXD48

D2 vs. B6

D2 vs. BXD14

BXD48 vs. B6

BXD48 vs. BXD14

B6 vs. BXD14

% Reduction in IOP

0.001

>0.05

>0.05

<0.001

>0.05

<0.05

>0.05

T max (h)

<0.0001

<0.05

<0.001

<0.0001

<0.05

<0.01

>0.05

T end (h)

<0.0001

<0.001

<0.0001

<0.0001

<0.001

<0.0001

>0.05

AUCtotal (% h)

0.0002

>0.05

<0.01

<0.001

>0.05

<0.01

>0.05

  1. Overall P-value represents the outcome of the one-way ANOVA analysis. Individual AUC-values represent the outcome of Tukey–Kramer multiple comparisons tests. AUCtotal (% h) area under the curve in percent IOP reduction x hours, T end (h) time to end of response in hours, T max (h) time to maximum response in hours
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