Table 3 Pharmacodynamic parameters after application of 0.9% pregabalin eye drops to Dutch belted rabbits

From: Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility

Pharmacodynamic parameters

(Mean ± SEM)

Baseline IOP (mmHg)

20.7 ± 0.5

IOP at T max (mmHg)

16.1 ± 1.4

∆IOP (mmHg)

−4.6 ± 0.6

% Reduction in IOP

22.1 ± 2.8

T max (h)

2.4 ± 0.6

T end (h)

6.0 ± 0.0

AUCtotal (% h)

78.2 ± 4.2

  1. AUCtotal (% h) area under the curve in percent IOP reduction x hours, T end (h) time to end of response in hours, T max (h) time to maximum response in hours
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