Fig. 2
From: Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder
Enrichment of meQTL target CpG sites in DNaseI hypersensitive sites. We identified the meQTL targets (at FDR 5% in peripheral blood, cord blood and lung, and past 1e–08 P value threshold in fetal brain results) in peripheral blood, cord blood, fetal brain, and lung as well those meQTL targets that were present in the overlap of peripheral blood with the other three tissues. Odds ratio and P value in gray text represent enrichment fold statistic and P value from Fisher’s exact tests examining the tendency of meQTL targets to overlap with DHS sites compared to CpG sites that were not meQTL targets. Odds ratio and P value in black text represent enrichment fold statistic and P value from Fisher’s exact tests examining the tendency of meQTL targets of significant (P value < = 1e–04) SNPs from the PGC cross-disorder results or their proxies (r 2 > = 0.8) to overlap with DHS sites compared to CpG sites that were not meQTL targets of the same SNPs. A full list of enrichment statistics and P value for both tests against a total of 181 cell-type-specific DHS sites, cell-type-specific chromatin marks, and transcription factor-binding sites is available in Supplementary Data 7 and 8
