Table 2 Enrichment statistics for meQTLs derived from 4 tissue types in ASD GWAS SNPs

From: Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder

 

ASD P value = 1e–03

ASD P value = 1e–04

 

meQTL P–value = 1e–08

meQTL P value = 1e–08

Fetal braina

1.70 (<0.001)

3.55 (<0.001)

 

meQTL FDR = 10%

meQTL FDR = 5%

meQTL FDR = 1%

meQTL FDR = 10%

meQTL FDR = 5%

meQTL FDR = 1%

Peripheral bloodb

1.22 (<0.001)

1.20 (<0.001)

1.23 (<0.001)

1.31 (0.001)

1.40 (<0.001)

1.58 (<0.001)

Cord bloodb

1.14 (0.032)

1.21 (0.011)

1.20 (0.023)

1.13 (0.299)

1.10 (0.392)

1.10 (0.406)

Lunga

—

1.09 (0.343)

—

—

0.80 (0.301)

—

  1. Enrichment fold statistics and P values based on 1000 permutations
  2. aLD pruning performed with 1000 Genomes CEU samples
  3. bLD pruning performed with the study-specific genotype data. See Methods for additional details
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