Table 3 Gene Ontology terms significantly enriched in multiple tissue types in comparison of ASD-related meQTL targets to meQTL targets generally
From: Cross-tissue integration of genetic and epigenetic data offers insight into autism spectrum disorder
Term | Peripheral blood scaled ranka | Cord blood scaled ranka | Fetal brain scaled ranka |
|---|---|---|---|
Response to interferon-gamma | 0.14 | 0.11 | 0.11 |
Positive regulation of relaxation of cardiac muscle | 0.20 | 0.46 | 0.30 |
Production of molecular mediator of immune response | 0.65 | 0.22 | 0.28 |
Cellular response to interferon-gamma | NA | 0.07 | 0.09 |
Detection of bacterium | NA | 0.18 | 0.06 |
Detection of biotic stimulus | NA | 0.26 | 0.04 |
T-helper 1 type immune response | NA | 0.08 | 0.34 |
Regulation of interleukin-10 secretion | NA | 0.09 | 0.43 |
Interferon-gamma production | NA | 0.57 | 0.19 |
Regulation of interleukin-4 production | NA | 0.24 | 0.62 |
Interleukin-4 production | NA | 0.29 | 0.60 |
Interleukin-10 production | NA | 0.25 | 0.74 |
Tongue development | NA | 0.68 | 0.32 |
Inflammatory response to antigenic stimulus | NA | 0.32 | 0.81 |
Endochondral bone growth | NA | 0.71 | 0.53 |
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 0.01 | 0.05 | NA |
T-cell costimulation | 0.05 | 0.01 | NA |
Positive regulation of hormone secretion | 0.09 | 0.04 | NA |
Antigen receptor-mediated signaling pathway | 0.08 | 0.13 | NA |
Immunoglobulin production involved in immunoglobulin mediated immune response | 0.24 | 0.03 | NA |
Single organismal cell-cell adhesion | 0.23 | 0.12 | NA |
Single organism cell adhesion | 0.34 | 0.16 | NA |
Negative regulation of nonmotile primary cilium assembly | 0.16 | 0.39 | NA |
Antigen processing and presentation of polysaccharide antigen via MHC class II | 0.02 | 0.58 | NA |
Polysaccharide assembly with MHC class II protein complex | 0.03 | 0.59 | NA |
Protein-carbohydrate complex subunit organization | 0.04 | 0.61 | NA |
Microtubule sliding | 0.29 | 0.38 | NA |
MHC protein complex assembly | 0.06 | 0.75 | NA |
Negative regulation of serine-type peptidase activity | 0.41 | 0.41 | NA |
Regulation of satellite cell activation involved in skeletal muscle regeneration | 0.39 | 0.45 | NA |
Protein repair | 0.43 | 0.43 | NA |
Regulation of serine-type peptidase activity | 0.48 | 0.47 | NA |
Protein localization to basolateral plasma membrane | 0.46 | 0.55 | NA |
Lymphocyte migration into lymphoid organs | 0.47 | 0.62 | NA |
Peyer’s patch morphogenesis | 0.60 | 0.70 | NA |
Regulation of homeostatic process | 0.45 | 0.92 | NA |
Skeletal muscle satellite cell activation | 0.88 | 0.63 | NA |
