Fig. 4
Independent validation of oncogenic pathway convergence. a CT diagnosis of synchronous lung and breast tumors in RJLC5 and RJLC6. Scale bar, 1 cm. b Circos plots highlighting different structural variations of lung and breast tumors in RJLC5 and RJLC6. RJLC5-Lung harbored c-METΔE14 and RJLC5-Breast harbored HER2Y777L; RJLC6-Lung harbored EGFR-KDD and RJLC6-Breast harbored HER4N855K. c CT diagnosis of MSLC and circos plots representation of somatic mutations in RJLC7. EGFRL858R identified in RJLC7-T1 was confirmed using ARMS PCR. Scale bar, 1 cm. d Time line of RJLC7 MSLC diagnosis and treatment. Baseline and 21-month CT scan for RJLC7 following treatment with gefitinib. Scale bar, 1 cm. e A schematic model showing that simultaneous evolutionary expansion and constraint of genomic heterogeneity collaboratively shape tumorigenic process and clonal architecture
