Table 1 Ligand structures and their hypercalcemia liability activities

From: HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions

 
  1. Chemical structures of ligands—natural agonist 1,25D3 and Cmpd1−3 (Supplementary Data 1)—are shown with their respective EC50s for BGLAP and TRPV6 gene activation assays, maximum stimulation values (normalized to the fold change of 1,25D3 treated cells over DMSO for both genes) and the number of independent biological replicates
  2. aThe secondary alcohol stereocenter is a single unknown configuration
  3. bBoth stereocenters are one single configuration. The configuration of the Ala stereocenter is known, the secondary alcohol configuration is not. EC50 values are the average from the replicate runs
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