Fig. 5
Clustering genes by expression profile reveals similar patterns in stressed BDNF+/+ and unstressed BDNFMet/+. a–e Genes were clustered based on their fold change in stressed BDNF+/+ (S), unstressed BDNFMet/+ (VM), and stressed BDNFMet/+ (VM + S) males and females versus unstressed BDNF+/+. Fold change direction and significance was determined as follows: up-regulated (z-score ≤ 0.001, fold change ≥ 1.5), down-regulated (z-score ≤ 0.001, fold change ≤ -1.5), or unaltered (z-score ≥ 0.001 and/or absolute fold change ≤ 1.5). Genes with the same expression profiles were clustered together. The maximum, mean, and minimum normalized read density for each clustered profile is presented as a line graph. GO analysis was performed using the DAVID database. The top five most enriched terms for each cluster are presented as a bar graph of their enrichment score (ES). Left: Females, Right: Males
