Table 1 Intrinsic electrophysiological properties of layer 2/3 neurons at P14

From: Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior

 

Control (n = 8 cells)

dnTCF4 (n = 11 cells)

P-value

 

Mean

s.d.

Mean

s.d.

 

Resting membrane potential (mV)

−58.68

11.58

−62.2

7.99

0.4423

Input resistance (MOhm)

35.1

14.96

26.04

9.491

0.1241

Tau (ms)

33.38

14.58

32.45

8.134

0.8596

Sag (mV)

1.235

1.537

0.4708

0.4513

0.8855

Spike threshold (mV)

−30.06

4.895

−29.55

5.781

0.8402

Rheobase (pA)

83.23

72.14

99.85

58.19

0.5853

Spike peak amplitude (mV)

58.45

11.66

56.22

8.986

0.643

Spike half width (ms)

2.326

1.029

2.197

0.412

0.7452

First interspike interval (ms)

19.63

14.12

14.96

4.243

0.428

Last interspike interval (ms)

47.71

20.65

44.44

16.84

0.7403

Adaptation (%)

50.43

13.01

55.25

8.396

0.4029

  1. To exclude the possibility that transient dnTCF4 overexpression may impair intrinsic electrophysiological properties of delayed CPNs, we compared 11 electrophysiological parameters in dnTCF4-electroporated neurons with control electroporated cells and did not find significant differences among the groups; n = 8 and 11 cells (Control and dnTCF4, respectively), Student’s t test. Thus, reduced activity of delayed CPNs is not related to detectable modification of intrinsic electrophysiological properties
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