Fig. 6

TRPV1-expressing sensory nerves protect against skin inflammation. a Bar charts illustrate ear thickness increment in wt mice pre-treated with either vehicle or RTX. Data are presented as mean ± SEM. Asterisks indicate statistical significance. *p < 0.05, Student’s t-test; b Bar charts illustrate ear thickness increment in wt, Trpa1 ^−/−, Trpv1 ^−/− and Trpa1 ^−/−/Trpv1 ^−/− dKO mice. Data are presented as mean ± SEM. Asterisks indicate statistical significance. *p < 0.05; **p < 0.01, ANOVA; c Representative H&E staining of ear skin sections from wt mice, pre-treated with vehicle or RTX; Scale bar, 100 µm; d Representative H&E staining of ear skin sections from wt, Trpa1 ^−/−, Trpv1 ^−/− and Trpa1 ^−/−/Trpv1 ^−/− dKO mice. Scale bar, 100 µm