Fig. 7
From: Sensory TRP channels contribute differentially to skin inflammation and persistent itch
TRPV1 deficiency promotes the function of dermal macrophages. a Representative FACS plots of macrophages in the ear preparations isolated from wt, Trpa1 −/−, Trpv1 −/−, and Trpa1 −/−/Trpv1 −/− dKO mice. Macrophages were defined as I-Ab-lo/- F4/80+ CD11b+ CD11c-; b, c Quantification of the number (b) and the percentage (c) of macrophages based on flow cytometry analysis. n = 3. Data are presented as mean ± SEM. NS, not significant. Asterisks indicate statistical significance. **p < 0.01; ***p < 0.001, ANOVA; d–f Expression of proinflammatory cytokines TNFɑ (d), IL-1β (e) and IL-6 (f), in the SADBE-treated ear preparations of wt, Trpa1 −/−, Trpv1 −/−, and Trpa1 −/−/Trpv1 −/− dKO mice. Data are presented as mean ± SEM. NS, not significant. Asterisks indicate statistical significance. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, ANOVA
