Fig. 1

Transcriptional and DNA methylation of a collection of organs of first and second trimester. a The collection of 111 samples analysed for gene expression (by next generation sequencing (NGS) DeepSAGE) and 105 samples analysed for DNA methylation (by Illumina 450 K array). See also Supplementary Data File 1. Mat, maternal. b Multidimensional scaling (Euclidian distance) of the transcriptional profiles of the 111 samples. The colors represent the different germ layers whereas the shapes indicate the gestational age. See also Supplementary Fig. 2a. c Multidimensional scaling (Euclidian distance) of the DNA methylation profiles of the 105 samples. The colors represent the different germ layers whereas the shapes indicate the gestational age. See also Supplementary Fig. 2b. d Hierarchical clustering (Euclidian distance) of the 105 DNA methylation samples. e Multidimensional scaling (Euclidian distance) of the DNA methylation profiles excluding the extraembryonic samples. The colors represent the different germ layers whereas the shapes indicate the gestational age. Dashed arrows represent the trend of DNA methylation dynamics during development in similar organs