Fig. 7 | Nature Communications

Fig. 7

From: Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism

Fig. 7

Overview of Fgf and Wnt signaling in rostral-caudal patterning of ESC-derived neuroectoderm. The processes of self-patterning in 3-D ESC culture. ESC differentiates into Fgf5+ epiblast. Six3+ rostral polarization is spontaneously generated. Localized Fgf signaling performs dual roles; in the early stage, suppression of Six3+ rostral cells in the presumptive caudal region; in the later stage, promotion of Wnt signaling. Localized Wnt signaling generates a Irx3+ caudal identity. Wnt antagonist and agonist gradients maintain a rostral-caudal neural pattern, which would be similar to the region from forebrain to midbrain in vivo

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