Fig. 7 | Nature Communications

Fig. 7

From: Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers

Fig. 7

Model of STIM1–Orai1 deactivation induced by Ca2+-CaM. Extracellular Ca2+ influxes after the formation of the STIM1–Orai1 complex, leading to elevation of cytosolic Ca2+. CaM undergoes a conformational change and binds to the exposed SOAR region of STIM1. The STIM1–Orai1 complex dissociates, the Orai1 channel is inactivated and the STIM1 oligomer is disassembled. As the cytosolic Ca2+ concentration is decreased, CaM dissociates from STIM1. STIM1 returns to the resting state, owing to a filled ER Ca2+ store and possibly other regulators

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