Table 1 Summary of the A-band width measurements based on IEM

From: The giant protein titin regulates the length of the striated muscle thick filament

 

Cardiac muscle

Skeletal muscle

 

WT

Ttn ΔC1-2

p-value

WT

Ttn ΔC1-2

p-value

SL range (ÎĽÎĽ)

~ 1.8–2.5

~ 1.8–2.6

 

~ 2.4–3.0

~ 2.4–3.0

 

A-band width (nm)

1608 ± 30

1435 ± 25

<0.0001

1580 ± 24

1412 ± 24

<0.0001

Δ A-band width (nm)

 

173 ± 4

  

168 ± 10

 

Δ per C-zone repeat (nm)

 

43.4

  

42.0

 
  1. Shrinkage-corrected A-band width is significantly shorter by 173 nm in cardiac and 168 nm in skeletal muscle of Ttn ΔC1-2 mice compared to wild type. Values are mean±s.d. Statistical analysis performed with a two-tailed t-test. See Supplementary Table 4 for additional statistical details. A total of 6 WT and 6 Ttn ΔC1-2 male mice at 8 weeks of age were used
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