Fig. 5
Replication of the early Aβ regions in BioFINDER. Comparison of 18F-flutemetamol SUVR between early accumulators (CSF+/PET−, n = 30) and non-accumulators (CSF−/PET−, n = 219) in BioFINDER to identify early Aβ regions. The highest significance was seen around the posterior regions of the cingulate cortex and the orbitofrontal cortex similar to the results in ADNI (Fig. 1a, b). Note that the BioFINDER analysis included cross-sectional data and fewer subjects compared to ADNI, which results in less statistical power. Voxelwise two-sample t-test was used. The significance threshold was set at p < 0.001 and the comparison was adjusted for age and gender. The red/yellow colors illustrate significant t values according to the scale on the left
