Table 1 Baseline characteristics of the ADNI cohort

		A	B	C	p-value
	Entire ADNI sample	CSF−/PET−	CSF+/PET−	CSF+/PET+	p-value
N	473	218	59	191
Baseline CN/MCI	37%/63%	47%/53%	44%/56%	23%/77%	A-B = 0.58
					B-C < 0.001
					A-C < 0.001
Age (years)	72.0 (7.0)	71.0 (7.0)	71.2 (8.1)	73.2 (6.3)	A-B = 0.99
					B-C = 0.20
					A-C < 0.001
Gender (women)	47%	47%	46%	48%	0.95
Education (years)	16.5 (2.6)	16.7 (2.6)	17.0 (2.2)	16.1 (2.6)	A-B = 0.47
					B-C = 0.007
					A-C = 0.03
Presence of the APOE ε4 allele	40%	16%	46%	65%	A-B < 0.001
					B-C = 0.004
					A-C < 0.001
MMSE (0–30 points)	28.4 (1.7)	28.8 (1.4)	28.8 (1.3)	27.9 (1.8)	A-B = 0.95
					B-C = 0.001
					A-C < 0.001
Baseline neocortical composite florbetapir SUVR¹	0.90 (0.21)	0.74 (0.05)	0.78 (0.06)	0.93 (0.09)	A-B < 0.001
					B-C < 0.001
					A-C < 0.001
Years between florbetapir PET scans (range)	2.0 (0.9–4.1)	2.0 (0.9–4.1)	2.0 (1.9–4.1)	2.0 (1.7–3.0)	1.0
Years between FDG PET scans (range)	2.0 (0.8–3.1)	2.0 (0.8–2.7)	2.1 (1.9–3.1)	2.0 (1.8–3.0)	0.72
Years between MRI scans (range)	2.0 (0.4–4.1)	2.0 (0.4–4.1)	2.0 (0.5–4.1)	2.0 (0.6–3.1)	0.92
Hippocampus volume (cm³)	7.2 (1.1)	7.5 (1.0)	7.5 (0.9)	6.9 (1.3)	A-B = 0.92
					B-C < 0.001
					A-C < 0.001
CSF Aβ42 (ng/L)	186 (52)	234 (27)	165 (23)	136 (22)	A-B < 0.001
					B-C < 0.001
					A-C < 0.001
CSF T-tau (ng/L)	79 (46)	59 (26)	60 (31)	109 (53)	A-B = 0.95
					B-C < 0.001
					A-C < 0.001
CSF P-tau (ng/L)	39 (23)	28 (12)	30 (26)	54 (25)	A-B = 0.19
					B-C < 0.001
					A-C < 0.001

CN cognitively normal, CSF cerebrospinal fluid, CSF+/− abnormal/normal CSF Aβ42 levels, MCI mild cognitive impairment, MMSE Mini Mental State Examination, N number of subjects, PET+/− abnormal/normal florbetapir SUVR, SD standard deviation, SUVR standardized uptake value ratio (using a composite reference region) corrected for partial volume errors. Comparison between non-accumulators (CSF−/PET−), early Aβ accumulators (CSF+/PET−), and late Aβ accumulators (CSF+/PET+). Values are given in mean (SD) if not otherwise specified. Groups were compared with Mann–Whitney U statistics if significant after the Kruskal–Wallis test. Significant p values are in bold. The CSF−/PET+group was not included in this table as a separate group since they were not used in any analysis and they were also too few to be used in the group comparisons (n = 5)

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