Table 3 Annual Aβ accumulation rates in the significant late Aβ regions in ADNI

From: Earliest accumulation of β-amyloid occurs within the default-mode network and concurrently affects brain connectivity

Region

CSF+/PET−

CSF+/PET+

p-value

Precentral, right

0.1% (−0.5–0.7)

2.1% (1.7–2.6)

0.000002

Postcentral, right

0.1% (−0.7–0.9)

2.3% (1.8–2.7)

0.000005

Pericalcarine, left

0.2% (−0.8–1.3)

2.8% (2.2–3.6)

0.000006

Postcentral, left

0.2% (−0.5–1.2)

2.4% (1.9–2.8)

0.000008

Precentral, left

0.3% (−0.3–1.0)

2.3% (1.9–2.9)

0.000024

Paracentral, left

0.6% (−0.2–1.4)

2.4% (1.9–2.8)

0.000057

Lingual, left

0.5% (−0.7–1.9)

2.8% (2.2–3.4)

0.00019

Lateral occipital, left

0.4% (−0.4–1.3)

2.3% (1.8–2.9)

0.00026

Pericalcarine, right

0.4% (−0.6–1.5)

2.9% (2.3–3.6)

0.0003

Paracentral, right

0.6% (−0.2–2.1)

2.2% (1.7–2.7)

0.00038

Fusiform, left

1.1% (0.3–2.0)

2.4% (2.0–2.8)

0.00049

Lingual, right

0.6% (−0.4–1.8)

2.8% (2.2–3.5)

0.0006

Cuneus, left

−0.3% (−1.2–0.8))

2.0% (1.4–2.8)

0.00062

Middle temporal, left

1.1% (0.3–2.0)

2.2% (1.9–2.6)

0.0007

Lateral occipital, right

0.6% (−0.1–1.4)

2.4% (1.9–3.1)

0.00088

Fusiform, right

0.9% (0.0–1.8)

2.4% (1.9–2.9)

0.0017

Inferior temporal, right

1.3% (0.5–2.2)

2.4% (1.9–2.8)

0.0022

Inferior temporal, left

1.5% (0.7–2.5)

2.6% (2.2–3.1)

0.003

Superior temporal sulcus, left

1.4% (0.6–2.3)

2.4% (1.9–2.8)

0.0047

Caudal middle frontal, left

1.3% (0.5–2.1)

2.5% (2.0–3.1)

0.0054

Superior parietal, left

1.0% (0.2–1.9)

1.9% (1.5–2.3)

0.0074

Superior frontal, left

1.2% (0.5–2.0)

1.9% (1.5–2.3)

0.013

  1. CSF+ cerebrospinal fluid Aβ42 < 192 ng/L, PET+ >0.872 SUVR, ROI region of interest, SUVR standardized uptake value ratio (using a composite reference region). Comparisons in ADNI between early Aβ accumulators (CSF+/PET−) and late Aβ accumulators (CSF+/PET+) to identify late stage Aβ accumulation regions. The analysis was performed using general linear models with the Aβ PET SUVR change/year in each ROI as the dependent variable and CSF/PET groups, sex, age, and time between PET scans as covariates. Data are given in mean values (95% CI of the mean) in order of significance and Aβ accumulation is shown in % yearly SUVR change. Only significant regions after the Benjamini & Hochberg correction are shown