Fig. 7
From: Combating subclonal evolution of resistant cancer phenotypes
Acquired sensitivity to drugs targeting post-chemotherapy phenotypes. a Drug response assay comparing pre- and post-doxorubicin patient #1 cancer cells’ sensitivity to drugs after 3-day treatment (fibroblast feeder system; CellTiter-Glo was used). b Indicated cells were treated with equimolar doses of trametinib and MK2206 for 3 days, followed by CellTiter-Glo (top); synergy analysis of 3.125 µM doses of these drugs (bottom). Expected is by Bliss independence; P-value is by Student’s t-test (two-tailed). Fibroblast feeder system was used and fibroblast signal was subtracted out in a, b and percentages are relative to DMSO control mean. Error bars show s.d. of four technical replicates
