Fig. 3

Novel fusion genes involving mir-33b in SREBF1. Breakpoints for 5ʹ and 3ʹ SREBF1 fusion transcripts (a). Gene symbols refer to the corresponding partner gene for each fusion transcript. Red marks in-frame fusions between partner gene coding sequences (CDSs) and blue other fusion transcripts with out-of-frame fusions between partner gene CDSs in bold italic font. Expression of miR-33b-5p (b) but not miR-33b-3p (c) was significantly increased in 13 tumors with 3ʹ SREBF1 fusions and miRNA expression data compared with tumors without fusions of the host gene. Samples with SREBF1 fusions are shown as filled circles for in-frame fusions between partner gene CDSs, open circles with thick line for out-of-frame fusions between partner gene CDSs, and open circles with thin line for all other fusion transcripts