Fig. 4
From: The molecular basis of phosphite and hypophosphite recognition by ABC-transporters
The conformational change between the open and closed structures of Ps_PtxB. a, b A comparison of the open (purple) and closed (beige) structure of Ps_PtxB, superimposed on lobe 2, showing the 60° rotation of one domain relative to the other around an axis that lies between the two domains (red arrow). c Superimposing the open and closed structures on lobe 2 (lobe 1 is shown in grey) shows that the spatial arrangement of Y49 and Y203 is conserved in both the open and closed states, whilst Y94 and D16, which both sit on flexible loop regions, undergo large conformational movements (blue arrows) of 7 and 4.5 Å (cα- cα), respectively. The phosphite is shown as spheres
