Fig. 4
From: Epigenome-wide association studies identify DNA methylation associated with kidney function
Enrichment analysis of CpGs significantly associated with eGFR for mapping into regions containing specific transcription factor binding sites. Y-axis: -log10(P-value) from a binomial test comparing the expected and observed numbers of significant CpGs that map into the binding site regions for a given transcription factor. X-axis: 169 evaluated transcription factors, listed in alphabetical order. Across 169 evaluated transcription factors, CpGs associated with eGFR at P<1e-05 in the meta-analysis of ARIC and FHS show significantly enriched mapping into regions that contain binding sites for transcription factors CEBPB, EBF1, and EP300 (red color). Enrichment testing was carried out using permutation with matching for genomic localization when sampling from the background. Statistical significance was set at P<3e-04 (red line), corresponding to a Bonferroni correction for 169 transcription factors
