Table 2 Replicated DNA methylation sites associated with eGFR. DNA methylation sites associated with eGFR (P<1e-5) in ARIC and FHS that were successfully replicated in the other cohort after correction for multiple testing (P Bonferroni<2.7e-4) and attained epigenome-wide significance (P meta<1e-7) in a fixed effects inverse-variance weighted meta-analysis of ARIC and FHS. The Bonferroni threshold was set at 2.7e-4 = 0.05/182, the number of unique CpG sites brought forward for replication in both ARIC and FHS

From: Epigenome-wide association studies identify DNA methylation associated with kidney function

Probe name

Chr

Position (b37)

Gene

ARIC discovery

FHS replication

Meta-analysis results

    

β

SE

P-value

β

SE

P-value(one-sided)

β

SE

P-value

DNA methylation sites associated with eGFR that were discovered in ARIC and replicated in FHS

 cg11950754

1

53782077

LRP8

−0.037

0.007

4.2E-07

−0.024

0.006

2.1E-05

−0.029

0.005

2.0E-10

 cg19497511

2

238609807

LRRFIP1

−0.034

0.008

7.2E-06

−0.020

0.006

2.3E-04

−0.025

0.005

3.5E-08

 cg00501876

3

39193251

CSRNP1

−0.069

0.009

2.9E-13

−0.030

0.007

7.2E-06

−0.044

0.006

3.6E-15

 cg04460609

4

16532808

LDB2

−0.041

0.008

1.4E-06

−0.022

0.006

1.4E-04

−0.028

0.005

7.8E-09

 cg09022230

7

5457225

TNRC18

−0.050

0.009

1.3E-07

−0.025

0.006

5.1E-05

−0.033

0.005

5.2E-10

 cg23597162a

7

28102341

JAZF1

−0.080

0.013

3.4E-10

−0.056

0.009

3.3E-11

−0.064

0.007

2.8E-19

 cg02059849

8

142437898

PTP4A3

0.048

0.009

8.8E-08

0.024

0.006

1.0E-04

0.032

0.005

7.7E-10

 cg10750182

10

73497514

C10orf105;CDH23

−0.060

0.012

7.3E-07

−0.033

0.008

1.6E-05

−0.041

0.007

5.0E-10

 cg06158227

15

43662311

TUBGCP4;ZSCAN29

−0.042

0.008

7.8E-08

−0.020

0.005

9.9E-05

−0.027

0.004

8.5E-10

 cg16428517

16

3317428

MEFV / ZNF263

−0.036

0.007

6.6E-07

−0.022

0.005

6.1E-06

−0.026

0.004

1.2E-10

 cg22515589

17

79426432

BAHCC1

0.036

0.008

8.7E-06

0.020

0.006

2.6E-04

0.025

0.005

6.4E-08

 cg17944885a

19

12225735

ZNF788/ZNF20

−0.038

0.007

1.6E-07

−0.047

0.006

1.0E-17

−0.044

0.004

1.2E-23

Probe name

Chr

Position (b37)

Gene

FHS discovery

ARIC replication

Meta-analysis results

    

β

SE

P -value

β

SE

P -value (one-sided)

β

SE

P -value

DNA Methylation sites associated with eGFR that were discovered in FHS and replicated in ARIC

 cg12065228

1

19652788

PQLC2

0.034

0.007

2.9E-07

0.032

0.009

1.1E-04

0.033

0.005

2.2E-10

 cg23597162a

7

28102341

JAZF1

−0.056

0.009

6.6E-11

−0.080

0.013

1.7E-10

−0.064

0.007

2.8E-19

 cg04036920

11

33562503

C11orf41

−0.069

0.010

1.1E-11

−0.065

0.016

3.4E-05

−0.068

0.009

2.4E-15

 cg19942083

12

7070562

PTPN6/PHB2

0.030

0.006

3.7E-06

0.038

0.009

2.0E-05

0.033

0.005

7.2E-10

 cg27660627

16

89461803

ANKRD11

−0.050

0.010

1.0E-06

−0.056

0.015

1.3E-04

−0.052

0.008

9.9E-10

 cg12116137

17

1576449

PRPF8

0.043

0.009

5.5E-06

0.040

0.011

1.3E-04

0.042

0.007

5.3E-09

 cg00994936

19

1423902

DAZAP1

0.040

0.008

3.9E-07

0.045

0.010

1.0E-05

0.041

0.006

3.3E-11

 cg17944885a

19

12225735

ZNF788/ZNF20

−0.047

0.006

2.0E-17

−0.038

0.007

8.0E-08

−0.044

0.004

1.2E-23

  1. aCpG sites with P<1e-5 in both ARIC and FHS
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