Table 1 Biological activity of rapalogs
From: Diversity oriented biosynthesis via accelerated evolution of modular gene clusters
Compound ID | Module organisation | FKBP12 K i (nM) | p-S6 IC 50 (nM) | S. cerevisiae MIC (μg mL −1 ) |
|---|---|---|---|---|
Rapamycin | Natural | 5.4 | <1 | <0.25 |
1 | Natural | 2.5 | N/A | <0.25 |
8 | +1 | 6.5 | N/A | <2 |
7 | −1 | 7.9 | 100 | <2 |
5 | −3 | 370 | 300 | <64 |
3 | −5 | 460 | >1900 | >64 |
2 | −6 | >1000 | 1000 | >64 |
