Fig. 5 | Nature Communications

Fig. 5

From: Experimental transfusion of variant CJD-infected blood reveals previously uncharacterised prion disorder in mice and macaque

Fig. 5

Detection of PrP in R5 myelopathic primate. Detection of PK-resistant abnormal PrP in myelopathic primates D7 and R5, and vCJD primates D6 and R3 by western blot analysis with Sha-31 anti-PrP antibody, after short-term (a) or long-term (b) exposure. OC occipital cortex, BS brainstem, upCS upper cervical cord; loCS lower cervical cord, LS lumbar cord. c Detection of abnormal PrPd deposits in spinal cord (12th thoracic level) of R5 primate with Sha-31 monoclonal antibody (50×). d Higher magnification of c showing perineuronal and synaptic PrP immunostaining (630×). e Detection of abnormal PrPd deposits in spinal cord (4th cervical level) of R5 primate with POM-1 monoclonal antibody (100×). f Detection of abnormal PrPd deposits in spinal cord (4th cervical level) of R5 primate with 12F10 monoclonal antibody (200×)

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