Fig. 8
From: Emergent patterns of collective cell migration under tubular confinement
Forward polarization is better established in bigger microtubes. a Representative images of PBD-YFP cells in a 75 μm diameter tubular tissue moving upward (cyan arrow). Green (red) arrows show the active PBD zones as marker of lamellipodia protrusion in (opposite to) the direction of tissue front (yellow dashed line) expansion. Time is given in h:min, scale bars: 20 μm. b Calculation of the average lamellipodia persistence parameter, \(v_p = \mathop {\sum }\nolimits_i v_i/\mathop {\sum }\nolimits_i \left| {v_i} \right|\), as a function of tube diameter, where v i are all the velocity vectors falling into the zones marked by the active PBD signal (see Methods for how the zones are determined). Each point denotes an independent experiment. t-test: **P < 0.01, NS non-significant
