Fig. 5

Metabolic pathway interactions can shape inter-species metabolic dependencies. The identified Nash equilibria for a arginine and glutamate and b glycine and threonine. Sample payoff matrices are given for the region of sustainable leakiness levels by 11 genotypes. Unidirectional dependency is the only possible equilibrium in this region for (arginine, glutamate) while cross-feeding is the only possible equilibrium for glycine and threonine. Metabolic maps show the metabolic pathways involved in the biosynthesis of the respective amino acids