Fig. 6 | Nature Communications

Fig. 6

From: Convenient iron-catalyzed reductive aminations without hydrogen for selective synthesis of N-methylamines

Fig. 6

Synthesis of pharmaceutical N, N-(di)methylamines from the corresponding aminesi. a iReductive amination protocol demonstrating for the preparation of existing drug molecules. b Selective introduction of N-methyl moiety in drug molecules iReaction conditions: 0.5 mmol amine, 50 mg Fe2O3/NGr@C (5 mol% Fe), 5 mmol of paraformaldehyde (150 mg), 0.5 mmol Na2CO3, 2 mL DMSO-water (1:1), 130 °C, 24 h, isolated yields

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