Fig. 2 | Nature Communications

Fig. 2

From: Downregulation of myostatin pathway in neuromuscular diseases may explain challenges of anti-myostatin therapeutic approaches

Fig. 2

Myostatin pathway in muscle biopsies. mRNA levels of either ACTIVIN A a, GDF11 b, GDF8 c, FSTN d, or ACTIVIN A e were measured by RT-qPCR in healthy controls (Ctrl, N = 9), Becker Muscular Dystrophy (BMD, N = 6), Duchenne Muscular Dystrophy (DMD, N = 17), Inclusion Body Myositis (IBM, N = 17), Facioscapulohumeral Dystrophy (FSHD, N = 13) or Limb Girdle Muscular Dystrophy (LGMD, N = 11) patients. Horizontal lines are medians, the extremities of the boxes are delimitated by the first and third quartile, and the whiskers correspond to the 10th and 90th percentile. A one-way ANOVA, followed by the Fisher’s Least Significant Difference multiple comparison test was performed. Degree of freedom = 5

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