Fig. 6
From: Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells
Human AML tumours express proximal tubule markers. a Representative immunofluorescence co-stainings for the melanocytic/AML marker HMB45/MART-1 and the proximal tubule epithelial markers NAPI2A, AQP1 and CD133 and distal tubule epithelial marker Tamm Horsfall glycoprotein (THP) in human renal AMLs (top row) and normal kidney (bottom row). Scale bars: 50 μm. b Relative mRNA abundance (renal AML vs. matched normal kidney) of three selected transcription factors (TAL1, HNF4A and TFEC) and three proximal tubule markers (FMO1, CUBN and VIL1) in seven human AML cases. The graph shows the values for each patient and the whisker plot depicts mean ± s.d. * denotes P < 0.05 and **P < 0.01 (Student’s t test) statistically significant different expression between AML and normal
