Fig. 5
From: Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA
Unique features of the Tra1 FAT and Kinase domains. a Open conformation of Tra1 pseudokinase. Comparison of the kinase domain in P. pastoris Tra1 and mTOR (PDB 4jsnB). b Helices (indicated by a triangle, residues K2686–K2741) in the TRD2 domain of Tra1 FAT (orange) shift by up to 14 Å toward the kinase domain (pink) in comparison to mTOR (gray). The first helix of the FATC part of the kinase in Tra1 is in red. c Hinge interface between the two lobes. Backbone of a putative helix from lobe B in red. Helices from the FAT domain (residues G2700–K2753) forming the bearing-like surface in brown. The position of the hinge within the full SAGA complex is highlighted at the top left
