Fig. 1 | Nature Communications

Fig. 1

From: A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family

Fig. 1The alternative text for this image may have been generated using AI.

Sequence and structural analysis of human NUDIX hydrolases. a Consensus phylogenetic tree of full length Human NUDIX proteins with posterior probabilities of each branch provided. Distinct groups with known structures are overlaid for comparison. MTH1 (purple) and NUDT15 (light blue); NUDT5 (gray) and NUDT14 (black); NUDT21 (pink) and NUDT2 (brown); NUDT6 (firebrick red), NUDT3 (yellow), and NUDT10 (orange). b Known structures of human NUDIX proteins modeled in cartoon format with the NUDIX box colored in blue, NUDIX fold domain in green, and remaining structure colored in gray. c Graphical representation of the different domains within the human NUDIX hydrolases

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