Fig. 9
From: Epigenetic targeting of bromodomain protein BRD4 counteracts cancer cachexia and prolongs survival
Cachectic cancer patients show increased levels of p-FoxO3Ser413 and p-AMPKThr172 in rectus abdominis muscle. a p-FoxO3 (Ser413) and p-AMPK (Thr172) levels were measured by immunoblot in rectus abdominis muscles from non-neoplastic patients (n = 8) and cachectic cancer patients (n = 15). GAPDH serves as loading control. Data are presented in scatter dot plot, lines at means ± SD. Statistical analysis was performed by using Student’s unpaired t-test. *p < 0.05; **p < 0.01. b Representative western blots from non-neoplastic patients (controls), colon cancer, and pancreatic cancer patients are shown
