Table 1 ZIKV epitopes and DENV2 variants

From: Dengue virus-reactive CD8+ T cells mediate cross-protection against subsequent Zika virus challenge

Peptidesa

Sequencesb

Conservationc

MR-prM 20–28

IS F A T TL GV

44%

DENV2-prM20–28

LLFKTEDGV

 

FSS/MR-prM 44–52

A T MS Y E CP M

44%

DENV2-prM44–52

DT I TYKCP L

 

FSS/MR-E 4–12

IG VSNRDFV

89%

DENV2-E4–12

IG I SNRDFV

 

FSS/MR-E 7–15

SNRDFVEG M

89%

DENV2-E7–15

SNRDFVEGV

 

FSS/MR-NS3 347–355

PS VRNGNEI

56%

DENV2-NS3347–355

PS I KAGNDI

 

FSS/MR-NS5 18–27

CA E A PN MK I I

50%

DENV2-NS518–27

E SEVPN L DI I

 
  1. aZIKV peptides in bold are positive as determined via ICS assays in DENV2-infected mice
  2. bAmino acid residues underlined are conserved between the ZIKV epitope and DENV2 variant
  3. c% shared amino acids between ZIKV and DENV2
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