Fig. 4

SERCA2 inhibits Piezo1-mediated poking-induced currents. a, Representative traces of poking-induced inward currents recorded at -60 mV in HEK293T cells with the indicated transfections. b and c, Scatter plots of the maximal poking-induced currents (b) and inactivation tau (c) of the indicated transfections. One-way ANOVA with multiple comparison test. d and f, Representative current traces of poking-induced inward currents recorded at -60 mV of either N2A (d) or HUVEC (f) cells transfected with the indicated conditions. e and g, Scatter plots of the maximal poking-induced currents of either N2A (e) or HUVEC (g) cells transfected with the indicated conditions. Unpaired student’s t-test. Data shown as mean ± s.e.m. ^* p < 0.05, ^** p < 0.01, ***p < 0.001