Fig. 1 | Nature Communications

Fig. 1

From: ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

Fig. 1

Proteomic analysis of membralin-interacting proteins. a Venn diagram showing the number of interacting proteins identified from cell lysates prepared in NP40 (red), Digitonin (yellow), and TritonX-100 (blue). b Among 180 proteins identified in the membralin interactome (see Supplementary Fig. 1), a heatmap of 14 known ERAD components is presented. The color intensity represents protein intensity (summed peptide area under the curve) (c) Interaction network of the membralin interactome by IPA. Three main ERAD subnetworks were highlighted in green (SYVN1 subnetwork), blue (AMFR subnetwork) and yellow (EMC subnetwork). Nicastrin was highlighted in orange color. Solid and dashed lines represent direct interactions and indirect interactions, respectively

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