Fig. 1
From: Structure of Rap1b bound to talin reveals a pathway for triggering integrin activation

Domain organization and a linear structural model of talin. The model was generated from known crystal and NMR structures of talin fragments and shown in cartoon representation. Critical talin-binding partners involved in talin membrane recruitment and activation are indicated in the figure. PIP2 phosphatidylinositol-4,5-bisphosphate, RIAM-N the N terminus of RIAM, PIPKIγ type I phosphatidylinositol phosphate kinase isoform-γ