Fig. 7
From: The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis
High Morgana levels in cancer cells induce NK cells recruitment at early phases of primary tumor formation. a, b Tumor weight a and percentage of immune cells (gated on CD45+ cells) b 4 days after subcutaneous injection of 4T1 cells EMPTY or shMORG1 and shMORG2 (n = 3 BALB/c mice per group). c Percentage of natural killer (NK) cells detected in the primary tumor of each mouse 4 days after injection of 4T1. d Gene expression analysis by Real-time PCR of HLA-F and HLA-B in MDA-MB-231. e, f Gene expression analysis by Real-time PCR of GM7030 gene (mouse ortholog of HLA-F) in 4T1 e and E0771 f EMPTY or shMORG1 and shMORG2. g Graph showing the tumor weight 30 days after injection of MDA-MB-231 EMPTY or shMORG1 and shMORG2 (n = 4 nude mice per group). h Tumor weight 30 days after subcutaneous injection of EMPTY or shMORG1 and shMORG2 BT549 cells (n = 4 nude mice per group). Bars in graphs represent standard errors (*p < 0.05; **p < 0.01; ***p < 0.001)
