Fig. 5 | Nature Communications

Fig. 5

From: Novel peptide probes to assess the tensional state of fibronectin fibers in cancer

Fig. 5

SPECT/CT images of mice bearing PC-3 xenografts 96 h post injection. Mice were injected with 15 MBq 111In-FnBPA5 a, c 111In-scraFnBPA5 b, d, respectively. Images were acquired post mortem 96 h post injection. In a, b dominant kidney uptake of both 111In-FnBPA5 and scrambled control peptide indicate unspecific clearance via the kidney. To assess additional information on peptide distribution within the body, kidneys were removed c and d. In c uptake in tumors and liver for 111In-FnBPA5 is shown, whereas the 111In-scraFnBPA5 control does not show any specific uptake in other organs. Results of SPECT/CT scans from individual subfigures are also shown in Supplementary Movies 1–4 showing 3D rotation movies of the respective scans

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