Fig. 1
From: T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes
Diversity and clonality indices of TCRB repertoire of CD4+ T cells. a The number of productive unique sequences (unique clonotypes) correlates with the cell number (Spearman's R = 0.85. p < 0.0001). b, c Sequencing data were normalized and true diversity indices b and Gini coefficients c were calculated (Methods section). TN cells from patients are less clonal than TN cells from healthy donors (Mann–Whitney U-test). Species is defined as a unique nucleotide sequence. d–f True diversity indices positively correlate among the TN, CM and Tscm cell subsets, consistent with CM and Tscm propagating from TN (Pearson's correlation). TN, true naive cells; CM, central memory cells; Treg, regulatory T cells; Tscm, stem cell-like memory T cells
