Fig. 2 | Nature Communications

Fig. 2

From: MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance

Fig. 2

Neuroendocrine differentiation can arise from acinar cells. a Gene set enrichment analysis (GSEA) demonstrating that genes upregulated in NEPC vs. PCA11 are enriched in the squamous subtype of pancreatic cancer, compared to all other individual subtypes (“REST”). b Pancreatic tissue from KCY mice was stained for SYP and YFP. SYP-YFP dual positive tumor cells are marked with white arrows. Scale bar indicates 10 μM. c CK-SYP dual positive cells are observed in serial-passaged patient-derived xenografts (PDXs). Both the primary patient sample and tissue after two passages through mice were stained with CK8/18 and SYP. Examples of co-stained cells are marked with white arrows. Corresponding H&E images are shown below. Scale bars indicate 100 μM

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