Fig. 3

Crystal structure of human TRIP13 in its ADP-bound state. a Surface and ribbon diagrams of C. elegans PCH-2 (PDB ID: 4XGU) in top and side views. Neighboring protomers are shown in different colors. b Ribbon diagram of the crystal structure of human TRIP13, with the bound ADP shown in sticks. c Overlay of the ribbon diagrams of the structures of human TRIP13 (orange) and the ADP-bound protomer of C. elegans PCH-2 (gray; except the pore loop, which is colored green), with the bound ADP molecules shown in sticks