Fig. 1

Hepatic PTPR-γ expression correlates with inflammation and insulin resistance in mice and humans. a Hepatic Ptprg mRNA expression level of 30-week-old wild-type mice fed either on a STD or a HCD (n = 8 per group). b Hepatic Ptprg mRNA expression level in mice treated with LPS or saline (n = 4 per group). c Hepatic PTPRG mRNA expression level in patients with non alcoholic fatty liver (NAFL) (n = 10) or non-alcoholic steatohepatitis (NASH) (n = 16) compared to healthy subjects (n = 19) from publicly available microarray E-MEXP-3291. d–h Correlation between hepatic PTPRG mRNA expression and d hepatic IkBA mRNA level, e hepatic IL6 mRNA level, f HOMA index, g plasma insulin level, and h glycemia in humans (n = 33). Error bars represent SEM. Statistical analyses were done using two-tailed unpaired Student’s t test. ^* P < 0.05. Correlation analyses were performed by using the Spearman rank-correlation test. See also Supplementary Fig. 1