Fig. 3
Hepatic overexpression of PTPR-γ is sufficient to cause insulin resistance. a Hepatic Ptprg mRNA expression, b body weight, c glycemia, and d cirucalting insulin level of 10-week-old STD-fed Ptprg −/− and Ptprg +/+ mice 10 days after infection with either control adenovirus (Ad-GFP) or adenovirus expressing mouse Ptprg (Ad-Ptprg) (n = 6–9/experimental group). e–k Values from 10-week-old FVB mice infected with either control adenovirus (Ad-GFP) or adenovirus expressing mouse Ptprg (Ad-Ptprg). e mRNA level from the liver (14 days post infection) (n = 8). f Glycemia and g insulinemia in basal and clamp condition (10 days post viral infection) (n = 7). h Glycemia during an insulin tolerance test (ITT; performed 12 days after viral infection; the dose of insulin used was 0.75 U/kg of body weight) (n = 7). i Glucose infusion rate over time, j glucose disposal rate, and k endogenous glucose appearance rate in basal and clamp condition (n = 7). Error bars represent SEM. Statistical analyses were done using two-tailed unpaired Student’s t test or using one-way ANOVA (Tukey’s post test). *P < 0.05; **P < 0.01, ***P < 0.001. See also Supplementary Fig. 5
