Fig. 4

In vivo kinetics of [¹⁸F]PARPi. JHU-LX48 SCLC PDX bearing mice (n = 3/group, 3 group, 9 mice total) were injected (i.v.) with 200–300 µCi of [¹⁸F]PARPi and imaged via PET/CT at 30, 60, and 120 min post injection. a Representative MIPs from a single mouse at all 3 time points. b Quantification of PET images for tumor and muscle grouped by time point (left) and grouped by organ (right). c Two phase decay curve showing wash out of the tracer from the muscle as the activity in the tumor site remains relatively constant after 60 min (left) along with resulting tumor to muscle ratios (right). Non-parametric Student’s t-test was used to calculate the statistics. **P < 0.01, ***P < 0.001. Error bars represent the SD