Fig. 5

Tumor size to [¹⁸F]PARPi uptake correlation. JHU-LX48 SCLC PDX bearing mice (n = 6) were injected (i.v.) with 200–300 µCi of [¹⁸F]PARPi and imaged. PET/CT imaging was performed once a week over 8 consecutive weeks starting one week after xenografting. a Representative MIPs from the same mouse over 8 weeks. b Quantification (n = 6) of mean uptake (top) and max uptake (bottom) of the PET images grouped by tumor size. Mean uptake was calculated to be 0.86 %ID/g across a large range, from 50–1300 mm³, of tumor sizes as quantified from CT VIOs. Small tumor sizes (<50 mm³) are likely affected by partial volume effect¹⁹. The figure includes the standard deviation as indicated by the shaded area. Non-parametric Student’s t-test was used to calculate the statistics. *P < 0.05; **P < 0.01. Error bars represent the SD