Fig. 3
From: Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task
vHPC theta–mPFC slow gamma coupling in Zdhhc8 +/− mice is inversely correlated with working memory performance. a Scatter plots depicting choice accuracy in a working memory task plotted against coupling strength between mPFC slow gamma and vHPC theta. Left: each session, right: each animal. Only Zdhhc8 +/− mice showed significant inverse correlation of choice accuracy with coupling strength (Individual sessions: wt; R = 0.14, p = 0.43, Zdhhc8 +/−; R = −0.45, p = 0.0089. Individual animals: wt; R = 0.34, p = 0.41, Zdhhc8 +/−; R = −0.67, p = 0.049). R: correlation coefficient. *p < 0.05. **p < 0.01; Pearson’s correlation. b Choice accuracy did not correlate with theta-slow gamma coupling within mPFC. (Individual sessions: wt; R = 0.21, p = 0.20, Zdhhc8 +/−; R = −0.25, p = 0.15. Individual animals: wt; R = 0.36, p = 0.38, Zdhhc8 +/−; R = −0.27, p = 0.48). R: correlation coefficient, Pearson’s correlation
